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Developing a vaccine

Option 1: You work for a pharmaceutical company and are developing a new vaccine to prevent Ebola. Since you are a genius and understand immunology well, you are asked to explain how a vaccine works in detail to the general public for a new ad campaign. Identify the sides of the immune system and cells involved and how they “teach” your immune system.
Option 2: Recently an experiment involving bone marrow transplants from CCR5 mutated (co-receptor on T cells) patients have been used as a method to treat for HIV patients to disrupt infections by allowing HIV binding to CD4 which prevents viral fusion and entry. Discuss the rationale behind this experiment.
Option 3: Compare and contrast the three lines of defense for the immune system. Option 4: Your patient has been infected by Methicillin-resistant Staphylococcus aureus (MRSA), an extracellular pathogen. Describe the mechanisms for B cell antigen presentation via MHC to T lymphocytes during an adaptive response.
Option 5: DiGeorge Syndrome is a genetic condition in which patients are born without a thymus whereas Aplastic Anemia is a potential adverse effect from drug toxicity (such as chemotherapy) and radiation poisoning that destroys bone marrow. Both of these result in different immunodeficiencies in patients. Which of these two conditions has the potential to have the most devastating consequences? Defend your answer.
Option 6: The complement cascade is an important contributor to the immune response within the bloodstream. Discuss the role of complement proteins in regard to eliminating pathogens that enter the body, particularly gram- negative bacteria and enveloped viruses.
Option 7: Transplantation of tissues and organs have become a common practice in medicine today. Explain the process of transplantation in regards to the immune system and why it is more complex than blood transfusions. Discuss the cells involved and the proteins/surface markers used for communication and recognition. Why would some cells be easier to transplant than others?
Option 8: Superantigens are special types of antigens found in different bacteria which are often toxins and can cause fatal immune responses such as septic shock. Discuss how superantigens contribute to immune responses and how heir effects differ from normal antigens.
Option 9: The Hygiene theory hypothesizes that living in an overly sterile environment may have negative effects on the immune system. In contrast, Severe Combined Immunodeficiency (SCID), also known as “bubble boy” syndrome, is a genetic condition in which leukocytes are unable to properly develop. Suppose two twins are kept in a completely sterile environment. One twin has a normal immune system, whereas the other has SCID. Discuss how each of the ns would react to an allergen like pollen compared to a bacterial infection.

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